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Omeros Announces Positive Data from OMS721 Phase 2 Clinical Trial in Renal Diseases

Business Wire (press release) - Oct 17, 2016
The IgA nephropathy patients demonstrated a clinically meaningful and statistically significant decrease in uACRs; lower uACRs are associated with improved renal survival. Treatment effects across the two patients were highly consistent. The mean ...

Rigel shaken after fostamatinib misses phase III trial target

PMLiVE - Oct 21, 2016
Fostamatinib is also in phase II trials for two other rare diseases - autoimmune haemolytic anaemia and IgA nephropathy. It was formerly partnered with AstraZeneca (AZ), but the UK pharma group handed back rights after it failed a trial comparing it to ...

XENT Breathes Easy, PTCT Suffers Translarna Snub, RTTR To Report Data In Q1

RTT News - Oct 18, 2016
(OMER) on Monday reported positive data from its phase II clinical trial of OMS721 for the treatment of kidney disorders, such as IgA nephropathy, membranous nephropathy, lupus nephritis, and complement component 3 glomerulopathy. According to the ...

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Iga Nephropathy books

IGA Nephropathy: Facts and Treatments

by: John Smith MA
IgA nephropathy is a chronic kidney illness that sometimes first appears during puberty and in young adults, affecting three times as many men as women. It is also known as IgAN, Berger’s disease, synpharyngitic glomerulonephritis and IgA nephritis. The disease is a form of glomerulonephritis - a condition where the kidneys’ glomeruli become inflamed. It typically follows an upper respiratory infection or a gastrointestinal infection. The disease is the most common type of glomerulonephritis.
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Pathogenesis and Treatment in IgA Nephropathy: An International Comparison

This book discusses the latest findings on the pathogenesis and treatment of IgA nephropathy. It particularly focuses on recently recognized initiation and progression factors and the varying treatment strategies in different regions, such as Asia, Europe, and the United States. More than 40 years have passed since Dr. Jean Berger first described primary IgA nephropathy (“Nephropathy with mesangial IgA-IgG deposits”) as a new disease entity.

Immunohistopathologically, IgA nephropathy is characterized by the granular deposition of IgA (IgA1) and C3 in the glomerular mesangial areas with mesangial cell proliferation and the expansion of mesangial matrices.
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Genetic studies of IgA nephropathy and Lupus nephritis: Genetic studies of glomerulonephritis

by: Mai Tuyet Vuong
The most important finding in these studies is the significant association between the low levels of sCD89-IgA complex in sera of IgA nephropathy patients and the progression of severe IgA nephropathy. One of our studies is the first investigation of the importance of IRF5, STAT4 and TRAF1-C5 gene polymorphisms in patients with IgA nephropathy and showed no evidence of an association of these genes with the development of IgA nephropathy or Lupus nephritis. The results did not suggest any overlap of genetic risk factors in the two diseases, even demonstrated a contrast between IgA nephropathy and Lupus nephritis.
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IgA Nephropathy

IgA nephropathy has, in the course of two decades, become one of the most important renal diseases. Not only is it the most common form of glo­ merulonephritis seen in many countries, its increasing recognition by renal biopsy in this time has allowed sufficient study to conclude that it is also one of the most frequent causes of end-stage renal failure. The clinical features are diverse, and only in a minority do recurrent macroscopic hematuric episodes associated with an upper respiratory tract infection allow a confident clinical diagnosis.
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Fostamatinib -- IgA Nephropathy (IgAN)

IgA nephropathy is the most common primary glomerular disease. IgA nephropathy is associated with inflammation in the kidneys and, for as many as 25% of ...

IgA Nephropathy - Mayo Clinic - New Treatment Option

Mayo Clinic' s Dr. Fernando Fervenza, M.D., Ph.D., discusses IgA nephropathy and a new treatment option for those with progressive nephropathy.

IgA nephropathy

Ayurvedic Treatment for IgA nephropathy, IgA nephropathy, IgA Nephropathy treatment, Proteins in Urine, Alternative to Dialysis, Alternative treatment for kidney ...

IgA Nephropathy 2015 update Prof Hussein Sheashaa 28 Nov 2015

IgA Nephropathy 2015 update Prof Hussein Sheashaa 28 Nov 2015.

Iga Nephropathy ¦ Treatment and Symptoms

http://tinyurl.com/IgaNephropathyIga Nephropathy treatment — Finding the right information about Iga Nephropathy treatment & symptoms, is crucial to ...